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📖 A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19

Goud et al • 1 January 2021

❦ ‘Although direct viral spread to distant organs is a possibility, release of inflammatory mediators and downstream messengers are also likely important effectors of physiological systems.

Major physiological systems affected in COVID-19 include, primarily, the respiratory and cardiovascular system, as well as the renal, hepatic, and nervous systems.’

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📖 (1 Jan 2021 ~ International Journal of Biological Sciences) A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19 ➤

C-19: Archives

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'The Approved List of biological agents'. Advisory Committee on Dangerous Pathogens / UKHSA.

On Hazard Group (HG) levels, the HSE, the UKHSA, COSHH, Notifiable Organisms, Notifiable Diseases, and SARS-CoV-2 in the UK

by United Kingdom Health Security Agency (UKHSA) / Health & Safety Executive (HSE) / Control of Substances Hazardous to Health Regulations (COSHH) / C19.Life • Updated 2026 • 7 May 2026

The Health and Safety Executive (HSE) has designated SARS-CoV-2, the virus that causes COVID-19, a Hazard Group 3 (HG3) pathogen that can cause severe human disease. The United Kingdom’s Health Security Agency (UKHSA) classifies SARS-CoV-2 as a notifiable organism, and COVID-19 as a notifiable disease (2026).

A raven’s overview

by Zdeněk Vrožin MBA • 25 January 2026

‘Prevention wasn’t impossible. It was withheld... In people with pre-existing dementia, SARS-CoV-2 infection is repeatedly associated with faster cognitive decline. For families, that can mean the difference between years at home and a rapid fall over months.’

✾ On SARS-CoV-2 infections (COVID-19), brain damage, neurological damage, and dementia

by C19.Life... et al • 21 November 2025

‘Although COVID-19 was originally considered a respiratory illness, it is now well established that SARS-CoV-2 infection can have far-reaching impacts on the nervous system. Common neurological symptoms in Long COVID [PASC] include new-onset cognitive difficulties, dysautonomia, fatigue, and peripheral neuropathy.’ from ‘Neuroimmune pathophysiology of long COVID’ by Moen et al / Psychiatry and Clinical Neurosciences (2025).

📖 Neurological and neurodevelopmental effects of Covid and MIS-C on children

by Byrne et al ~ Nature Pediatric Research / Bioengineer • 11 November 2025

‘The pediatric population, once thought to be relatively spared from severe outcomes, has presented with significant neurological manifestations that raise concerns about the short- and long-term effects of SARS-CoV-2 on the developing nervous system.’

Knock-knock... It’s mild!

by C19.Life • 5 November 2025

“How mild can a disease be?”

A WHO’s Who of VOCs, VOIs and VUMs: Alphabet Stew and Numeric Ragout for Dummies

by C19.Life • 1 November 2025

“We’re going to need a bigger Greek alphabet.”

📖 Guidance for Healthcare Employers and Workers on the use of Fluid Resistant Surgical Masks (FRSM) and respirators (FFP3 etc) to comply with the requirements of COSHH (2002) (England) (Updated 2025)

by The British Occupational Hygiene Society ~ COSHH and Healthcare Respiratory Protection • 20 October 2025

‘FRSMs [Surgical Masks] have never been considered either adequate or suitable equipment for protection against inhalable or respirable risks under COSHH.’

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