π On lymphocytopenia (lymphopenia)
β¦ ‘The most common causes of acquired lymphocytopenia include:
β² Protein-energy undernutrition.
β² HIV infection.
β² COVID-19.
β² Certain other viral infections.
Patients with HIV infection routinely have lymphocytopenia, which arises from destruction of CD4+ T cells infected with the HIV virus.
Patients with
COVID-19 also frequently have lymphocytopenia
(35%
to
83%
of patients).
Lower lymphocyte counts portend a poor prognosis and an increased likelihood of requiring ICU admission and of dying from the disease.
The cause of the lymphocytopenia is not completely understood, but COVID-19 can directly infect lymphocytes, and a cytokine-related apoptosis of the cells is likely.
β² Lymphocytopenia is most often due to AIDS, and recently COVID-19, or undernutrition, but it also may be inherited or caused by various infections, drugs, or autoimmune disorders.
β² Patients have recurrent viral, bacterial, fungal, or parasitic infections.’
β
π (Accessed 16 Sep 2023 ~ Merck & Co.) Entry for 'Lymphocytopenia' in Merck Manual β€
© 2023
Merck & Co.
π (Accessed 16 Sep 2023 ~ Merck & Co.) Entry for 'Lymphocytopenia' in Merck Manual β€
© 2023 Merck & Co.
