❦ ‘The most common causes of acquired lymphocytopenia include:

➲ Protein-energy undernutrition.

➲ HIV infection.

➲ COVID-19.

➲ Certain other viral infections.

Patients with HIV infection routinely have lymphocytopenia, which arises from destruction of CD4+ T cells infected with the HIV virus.

Patients with COVID-19 also frequently have lymphocytopenia (35% to 83% of patients).

Lower lymphocyte counts portend a poor prognosis and an increased likelihood of requiring ICU admission and of dying from the disease.

The cause of the lymphocytopenia is not completely understood, but COVID-19 can directly infect lymphocytes, and a cytokine-related apoptosis of the cells is likely.

➲ Lymphocytopenia is most often due to AIDS, and recently COVID-19, or undernutrition, but it also may be inherited or caused by various infections, drugs, or autoimmune disorders.

➲ Patients have recurrent viral, bacterial, fungal, or parasitic infections.’

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📖 (Accessed 16 Sep 2023 ~ Merck & Co.) Entry for 'Lymphocytopenia' in Merck Manual ➤

© 2023 Merck & Co.

📖 (Accessed 16 Sep 2023 ~ Merck & Co.) Entry for 'Lymphocytopenia' in Merck Manual ➤

© 2023 Merck & Co.