❦ Strikingly, the [foetal brain] haemorrhages are predominantly found in the late first and early second trimester of gestation, a period of development in which the effect of the COVID-19 pandemic has not been thoroughly investigated.

Specifically, the majority were between 12 and 14 PCW [post-conception week], a critical window of human foetal brain development when the endothelial tight junctions increase to form the blood-brain barrier.

Our observations of disrupted foetal cerebral vasculature are consistent with reports of damage to the microvasculature of the adult brain in SARS-CoV-2 infected patients.

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📖 (16 Jan 2023 ~ Brain) Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection ➤

© 2023 Massimo et al / Brain.